Ethanol → HCID 24985023, 화합물

HRID 388131노트

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HRID 388131 반응식
[C:1]1([C@H:7]([NH:9][C:10]2[C:15]([N+:16]([O-])=O)=CN=[C:12]([C:19]3[CH:28]=[CH:27][CH:26]=[C:25]4[C:20]=3[CH:21]=[CH:22][CH:23]=[N:24]4)[CH:11]=2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1([C@H](NC2C=C(C3C=CC=C4C=3C=CC=N4)N=C[C:39]=2[NH2:54])C)C=CC=CC=1.[H][H].[CH2:57]([OH:59])C>[Pd]>[C:1]1([C@H:7]([N:9]2[C:10]3[C:15](=[N:54][CH:39]=[C:12]([C:19]4[CH:28]=[CH:27][CH:26]=[C:25]5[C:20]=4[CH:21]=[CH:22][CH:23]=[N:24]5)[CH:11]=3)[NH:16][C:57]2=[O:59])[CH3:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 86626409HCID 86626409, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 24985023HCID 24985023, 화합물수율 97.9%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

((1R)-1-phenylethyl)(3-amino-6-(5-quinolyl)(4-pyridyl))amine ((1R)-1-Phenylethyl)(5-nitro-2-(5-quinolyl)(4-pyridyl))amine (500 mg, 1.35 mmol) was dissolved in ethanol (100 mL). Palladium on carbon (70 mg) was added followed by a hydrogen balloon. The reaction was stirred at room temperature for 18 h, then filtered through celite. The filtrate was condensed under reduced pressure to afford the desired product (450 mg, 97.9%). (MS (ESI) m/z 341 [M+1]+.

후처리

  1. filtrationfiltered through celite
  2. customcondensed under reduced pressure

출처 및 근거

ORD 기록
ord-ebef9d952b684c2ca9414dd62f5fef6f
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372976B2

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