Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-Naphthylglycolic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Naphthalenecarboxaldehyde | HCID 6201 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | beta-Cyclodextrin | HCID 444041 | — |
| 촉매 | Benzyl triethylammonium chloride | HCID 66133 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 2-Naphthylglycolic acid | HCID 11138143 | 4,209.8% |
반응 단계
A solution of 2-naphthaldehyde (2.0 g, 1.0 eq), benzyltriethylammonium chloride (BTEAC) (0.13 g), and 50% aqueous NaOH (2.3 mL), and β-cyclodextrin (0.10 g) in chloroform (10 mL) was heated at 55° C. for 12 hours. The mixture was then poured into water and the solution washed with EtOAc. The aqueous layer was then acidified to pH 1 by dropwise addition of HCl (conc.). This was extracted with EtOAc, dried over Na2SO4, filtered and concentrated under reduced pressure to yield a yellow oil (0.75 g, 29%) that was not further purified.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08377930B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-88020106d14d4aa3a2087b5944e3fbfc |
| 출처 메모 | uspto-grants-2013_02 |