Sulfuric Acid → Methyl alpha-phenylbenzeneacetate

HRID 388257

반응식

HRID 388257 반응식
[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(=O)(=O)(O)O.[C:22]([O-])(O)=O.[Na+]>CO>[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([O:10][CH3:22])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 8333Diphenylacetic AcidHCID 516892Sodium Bicarbonate

생성물 1

HCID 77019Methyl alpha-phenylbenzeneacetate수율 93%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a stirred solution of 2,2-diphenylacetic acid (1 gram, 1 equiv) in dry MeOH (50 mL) was added sulfuric acid (0.4 mL) dropwise and heated to reflux. Stirring was then continued for 3 hours. The reaction mixture was then cooled and poured into saturated aqueous NaHCO3 and extracted with EtOAc. The combined organic fractions were dried over Na2SO4, filtered, and concentrated under reduced pressure to yield an oil (1.0 g, 93%) that was not further purified.

후처리

  1. temperatureheated to reflux
  2. temperatureThe reaction mixture was then cooled
  3. extractionextracted with EtOAc
  4. dry with materialThe combined organic fractions were dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4fd80ac317c540d0a47855ff3d37e48b
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08377930B2

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