2-Methoxypyridine-3,4-diamine → 2-(2-Methoxy-4-methoxycarbonyl-phenyl)-5H-imidazo[4,5-c]pyridin-4-one hydrochloride

HRID 3883노트

반응식

HRID 3883 반응식
C[O:2][C:3]1[C:8]([NH2:9])=[C:7]([NH2:10])[CH:6]=[CH:5][N:4]=1.CO[C:13]1[CH:21]=[C:20]([C:22]#N)[CH:19]=[CH:18][C:14]=1[C:15]([OH:17])=[O:16].[Cl:24][CH:25](Cl)C.[CH2:28]([OH:30])C>>[ClH:24].[CH3:28][O:30][C:21]1[CH:13]=[C:14]([C:15]([O:17][CH3:25])=[O:16])[CH:18]=[CH:19][C:20]=1[C:22]1[N:9]=[C:8]2[C:3](=[O:2])[NH:4][CH2:5][CH:6]=[C:7]2[N:10]=1

참가 물질

4

반응물 3

HCID 101489982-Methoxypyridine-3,4-diamineHCID 151660044-Cyano-2-methoxybenzoic acidHCID 18381953Dichloroethane ethanol

생성물 1

HCID 704203902-(2-Methoxy-4-methoxycarbonyl-phenyl)-5H-imidazo[4,5-c]pyridin-4-one hydrochloride

실험 절차

Prepared analogously to Example 1 from 2-methoxy-3,4-diaminopyridine and 2-methoxy-4-cyano-benzoic acid. The product mixture obtained is digested with dichloroethane/ethanol (3:1). The undissolved material is filtered off, and the solution is evaporated and boiled with methanolic hydrochloric acid. On cooling, the product crystallizes out in the form of the hydrate.

후처리

  1. customThe product mixture obtained
  2. filtrationThe undissolved material is filtered off
  3. customthe solution is evaporated
  4. temperatureOn cooling
  5. customthe product crystallizes out in the form of the hydrate

출처 및 근거

ORD 기록
ord-1bcc2a3d16bb4766b58a295e2fc2fc6b
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04722929

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