2-(2-Chloro-4-fluorophenyl)acetamide → (+/-)-Trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(2,4-dichlorophenyl) pyrrolidine-2,5-dione

참여 물질

역할	이름	HCID	투입량
반응물	2-(2-Chloro-4-fluorophenyl)acetamide	HCID 2773716	—
반응물	2,4-Dichlorobenzeneacetamide	HCID 17190888	—
생성물	(+/-)-Trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(2,4-dichlorophenyl) pyrrolidine-2,5-dione	HCID 86608199	—

반응 단계

(±)-Trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1yl)-4-(2,4-dichlorophenyl)pyrrolidine-2,5-dione was prepared according to Example 40 replacing 2-chloro-4-fluorophenylacetamide with 2,4-dichlorophenylacetamide. Yield 20.9 mg, 5.2%. 1H NMR (DMSO-d6) 400 MHz δ: 11.65 (s, 1H), 7.69 (s, 1H), 7.51 (d, 1H, J=8.0 Hz), 7.43 (d, 1H, J=8.0 Hz), 7.34 (s, 1H), 7.12 (m, 1H), 6.87 (m, 2H), 4.65 (d, 1H, J=7.6 Hz), 4.55 (d, 1H, J=7.6 Hz), 4.10 (t, 2H, J=6.0 Hz), 2.90 (t, 2H, J=6.0), 2.12 (t, 2H, J=6.0 Hz).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08377927B2
출처 데이터셋	uspto-grants-2013_02
ORD ID	ord-7275c857681f402d864f6428366154cf
출처 메모	uspto-grants-2013_02