Trifluoroacetic acid → 6-Oxa-9-azaspiro(4.5)decane
반응식
[CH2:1]1[C:5]2([CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7][O:6]2)[CH2:4][CH2:3][CH2:2]1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:4]1[C:5]2([CH2:10][NH:9][CH2:8][CH2:7][O:6]2)[CH2:1][CH2:2][CH2:3]1참가 물질
4
실험 절차
To a of solution 1,1-dimethylethyl 6-oxa-9-azaspiro[4.5]decane-9-carboxylate (200 mg, 0.829 mmol, available from Tyger Scientific Inc) in DCM (3 ml) was added trifluoroacetic acid (TFA) (0.5 ml). The resulting colourless yellow solution was stirred at room temperature for 24 hr. The solvent was evaporated to give the title compound as a grey oil (203 mg).
후처리
- customThe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-a356f63a3fe44678bc8ca45e60b4ef6d
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08524751B2
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