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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Dimethylformamide → (R)-3-[1-(4,6-dimethyl-1,2-benzisothiazol-3-ylmethyl)-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl]-butyric acid methyl ester

HRID 388469
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인쇄 미리보기

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HRID 388469 반응식
[CH3:1][O:2][C:3](=[O:19])[CH2:4][C@H:5]([N:7]1[C:16](=[O:17])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[NH:9][C:8]1=[O:18])[CH3:6].Br[CH2:21][C:22]1[C:26]2[C:27]([CH3:32])=[CH:28][C:29]([CH3:31])=[CH:30][C:25]=2[S:24][N:23]=1.C(=O)([O-])[O-].[K+].[K+].CN(C=O)C>O>[CH3:1][O:2][C:3](=[O:19])[CH2:4][C@H:5]([N:7]1[C:16](=[O:17])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]([CH2:21][C:22]2[C:26]3[C:27]([CH3:32])=[CH:28][C:29]([CH3:31])=[CH:30][C:25]=3[S:24][N:23]=2)[C:8]1=[O:18])[CH3:6]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 584973913-Bromomethyl-4,6-dimethyl-benzo[d]isothiazoleHCID 68728457(R)-3-(2,4-Dioxo-1,4-dihydro-2H-quinazolin-3-yl)-butyric acid methyl ester

생성물 1

HCID 68751053(R)-3-[1-(4,6-dimethyl-1,2-benzisothiazol-3-ylmethyl)-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl]-butyric acid methyl ester수율 93%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

(R)-3-(2,4-Dioxo-1,4-dihydro-2H-quinazolin-3-yl)-butyric acid methyl ester (124 mg, 0.5 mmol) (prepared according to example 4, steps 1-2), 3-bromomethyl-4,6-dimethyl-1,2-benzisothiazole (150 mg, 0.59 mmol) (prepared according to example 5, steps 1-6), and potassium carbonate (345.5 mg, 2.5 mmol) are combined in a reaction vial and DMF (1 mL) is added. The reaction mixture is agitated at ambient temperature for 18 hours then diluted with water (15 mL). The product is isolated by filtration and purified by flash chromatography using an ethyl acetate/hexane gradient to provide (R)-3-[1-(4,6-dimethyl-1,2-benzisothiazol-3-ylmethyl)-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl]-butyric acid methyl ester (196 mg, 93%).

후처리

  1. additionis added
  2. customThe product is isolated by filtration
  3. custompurified by flash chromatography

출처 및 근거

ORD 기록
ord-c6a92ba26d4c4c9f9edd014e772ef8a5
출처 데이터셋
uspto-grants-2013_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08377949B2

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