Triethylamine → (S)-2-(2-amino-5-methoxy-benzoylamino)-hexanoic acid methyl ester

참여 물질

역할	이름	HCID	투입량
반응물	Triethylamine	HCID 8471	—
반응물	6-methoxy-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione	HCID 294479	—
반응물	methyl (2S)-2-aminohexanoate hydrochloride	HCID 14039065	—
용매	Dimethylformamide	HCID 6228	—
용매	Ethyl Acetate	HCID 8857	—
생성물	(S)-2-(2-amino-5-methoxy-benzoylamino)-hexanoic acid methyl ester	HCID 68727802	27%

반응 단계

To a mixture of 5-methoxy-isatoic anhydride (1.0 g, 5.18 mmol) and (S)-2-amino-hexanoic acid methyl ester hydrochloride (1.4 g, 7.71 mmol) (prepared according to example A) in DMF (10 mL) is added triethylamine (2.0 mL, 11.48 mmol). The mixture is stirred at room temperature for 16 hours. The reaction mixture is diluted with EtOAc (100 mL) and washed with H2O (50 mL×3). The organic layer is dried over sodium sulfate, concentrated and the residue is purified by flash chromatography with 60% EtOAc in Hexane as the eluent to afford (S)-2-(2-amino-5-methoxy-benzoylamino)-hexanoic acid methyl ester (410 mg, 27%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08377949B2
출처 데이터셋	uspto-grants-2013_02
ORD ID	ord-b0d3c116923244c6922301272b5d72f6
출처 메모	uspto-grants-2013_02