1-(Benzyloxy)-2,5-difluoro-4-nitrobenzene → 4-Amino-2,5-difluorophenol

HRID 388514노트

반응식

HRID 388514 반응식
C([O:8][C:9]1[CH:14]=[C:13]([F:15])[C:12]([N+:16]([O-])=O)=[CH:11][C:10]=1[F:19])C1C=CC=CC=1>CO.[Pd]>[NH2:16][C:12]1[C:13]([F:15])=[CH:14][C:9]([OH:8])=[C:10]([F:19])[CH:11]=1

참가 물질

4

반응물 1

HCID 574708681-(Benzyloxy)-2,5-difluoro-4-nitrobenzene

생성물 1

HCID 27787624-Amino-2,5-difluorophenol수율 99%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 1-(benzyloxy)-2,5-difluoro-4-nitrobenzene (9.21 g) in methanol (300 ml) was added 10% palladium on carbon (921 mg), and the mixture was stirred at room temperature for 24 hours and 20 minutes under a hydrogen atmosphere. After terminating the reaction by substituting the atmosphere in the flask with nitrogen, the catalyst was filtered using Celite. The filtrate was distilled off under reduced pressure to give the title compound (4.96 g, 99%) as a brown solid.

후처리

  1. customAfter terminating
  2. customthe reaction
  3. filtrationthe catalyst was filtered
  4. distillationThe filtrate was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-9becd02f3430401c961afb6112be4201
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08377938B2

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