Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1-Benzoyl-3-[1(naphth-1-ylmethyl)piperid-4-yl]urea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 1-Chloromethylnaphthalene | HCID 6845 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Benzoylureidopiperidine | HCID 12608582 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-Benzoyl-3-[1(naphth-1-ylmethyl)piperid-4-yl]urea | HCID 12942301 | — |
반응 단계
1-Chloromethylnaphthalene (0.88 g, 0.005 m), 4-benzoylureidopiperidine (1.28 g, 0.005 m) and triethylamine (0.6 g) in dimethylformamide (25 cm3) were stirred at room temperature for 24 hours. Water was added and the precipitated solid filtered off. The solid was suspended in isopropylalcohol and acidified with ethanolic HCl. The title compound was filtered off and dried as the hydrochloride salt, hemihydrate (1.2 g), m.p. 185°-186° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04722930 |
| 출처 데이터셋 | uspto-grants-1988_02 |
| ORD ID | ord-6c695e0fc6704fb0ad8fd2c49b74c803 |
| 출처 메모 | uspto-grants-1988_02 |