n-(6-Acetyl-3-chloro-4-methoxyphenyl)-4-isopropylthiazole-2-carboxamide → HCID 178486752, 화합물

HRID 388670노트

반응식

HRID 388670 반응식
[C:1]([C:4]1[C:9]([NH:10][C:11]([C:13]2[S:14][CH:15]=[C:16]([CH:18]([CH3:20])[CH3:19])[N:17]=2)=O)=[CH:8][C:7]([Cl:21])=[C:6]([O:22][CH3:23])[CH:5]=1)(=[O:3])[CH3:2].C(C1N=C(C2C=C(O)C3C(=CC(OC)=CC=3)N=2)SC=1)(C)C>>[Cl:21][C:7]1[CH:8]=[C:9]2[C:4]([C:1]([OH:3])=[CH:2][C:11]([C:13]3[S:14][CH:15]=[C:16]([CH:18]([CH3:20])[CH3:19])[N:17]=3)=[N:10]2)=[CH:5][C:6]=1[O:22][CH3:23]

참가 물질

3

반응물 2

HCID 66650598n-(6-Acetyl-3-chloro-4-methoxyphenyl)-4-isopropylthiazole-2-carboxamideHCID 178487691HCID 178487691, 화합물

생성물 1

HCID 178486752HCID 178486752, 화합물수율 70%

실험 절차

7-Chloro-2-(4-isopropylthiazol-2-yl)-6-methoxyquinolin-4-ol 218g was synthesized from compound 217g as a yellow solid in 70% yield, according to the procedures as described for compound 218a. MS (ESI, EI+): m/z=335 (MH+).

출처 및 근거

ORD 기록
ord-9af1055517db4b2b876046959213fb1c
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08377962B2

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