Ethyl 4,6-dimethoxypyrimidine-2-carboxylate → 4,6-Dimethoxypyrimidin-2-carboxylic acid amide

반응식

C([O:3][C:4]([C:6]1[N:11]=[C:10]([O:12][CH3:13])[CH:9]=[C:8]([O:14][CH3:15])[N:7]=1)=O)C.[NH3:16].CO>>[CH3:15][O:14][C:8]1[CH:9]=[C:10]([O:12][CH3:13])[N:11]=[C:6]([C:4]([NH2:16])=[O:3])[N:7]=1

참가 물질

반응물 2

HCID 4449183Ethyl 4,6-dimethoxypyrimidine-2-carboxylate

HCID 21705897Ammonia methanol

생성물 1

HCID 582826824,6-Dimethoxypyrimidin-2-carboxylic acid amide수율 100%

실험 절차

Ethyl-4,6-dimethoxy-pyrimidin-2-carboxylate (25 g, 1 eq.) in NH3/MeOH (7 M, 15 mL) was irradiated in a microwave reactor at 100° C. for 15 min. The solution was concentrated in vacuo to yield compound 286 as a beige solid in 100% yield. MS (ESI, EI+): m/z=184 (MH+).

후처리

concentrationThe solution was concentrated in vacuo

출처 및 근거

ORD 기록: ord-600a8277bf8d4da6bba358821674bd78
출처 데이터셋: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08377962B2

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