Dimethylformamide → 4-(5-Amino-1,3,4-oxadiazol-2-yl)-3-ethyl-2-methylphenol
반응식
[N:1]#[C:2]Br.[CH2:4]([C:6]1[C:15]([CH3:16])=[C:14]([OH:17])[CH:13]=[CH:12][C:7]=1[C:8]([NH:10][NH2:11])=[O:9])[CH3:5].C(=O)([O-])O.[Na+].CN(C=O)C>O>[NH2:1][C:2]1[O:9][C:8]([C:7]2[CH:12]=[CH:13][C:14]([OH:17])=[C:15]([CH3:16])[C:6]=2[CH2:4][CH3:5])=[N:10][N:11]=1참가 물질
6
실험 절차
196 mg of cyanogen bromide are added dropwise to a solution of 300 mg of 2-ethyl-4-hydroxy-3-methylbenzohydrazide in 50 ml of water, 130 mg of sodium hydrogencarbonate and 4 ml of DMF. A gas forms and a precipitate deposits. The latter is filtered off with suction and purified by column chromatography on silica gel, giving 40 mg of 4-(5-amino-1,3,4-oxadiazol-2-yl)-3-ethyl-2-methylphenol as colourless powder; MS-FAB (M+H+)=220; Rf (polar method): 1.43 min;
후처리
- filtrationThe latter is filtered off with suction
- custompurified by column chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-cca37965340a499c8b8cfb5de7a3c74d
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08377975B2
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