참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,3-Dibromopropane | HCID 8001 | — |
| 반응물 | Phenylacetonitrile | HCID 8794 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Toluene water | HCID 22272177 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-Phenylcyclobutanecarbonitrile | HCID 84400 | 64.9% |
반응 단계
Sodium hydride (1.54 g, 64.1 mmol) dissolved in DMF (15 ml) and cooled to 0° C. Phenyl acetonitrile (3 g, 25.6 mmol) and 1,3-dibromopropane (5.2 g, 25.6 mmol) were dissolved in DMF (15 ml) and added to above mixture drop-wise at 0° C. This mixture was heated to rt and continued stirring for 2 h. Work up (H2O/Toluene) afforded the title compound (2.61 g) as crude, which was used in the next without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08377970B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_02 |
|---|
| ORD ID | ord-ab72727df51f4f6ca5969b20ac909818 |
|---|
| 출처 메모 | uspto-grants-2013_02 |
|---|
