Toluene → 3-(3-Methoxyphenyl)-1H-pyrrole-2,5-dione

HRID 388861노트

반응식

HRID 388861 반응식
C1(C)C=CC=CC=1.CS(O)(=O)=O.[C:13]1(=[O:19])[O:18][C:16](=O)[CH:15]=[CH:14]1.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24](N)[CH:23]=1.C([N:31](CC)CC)C>>[CH3:20][O:21][C:22]1[CH:23]=[C:24]([C:15]2[C:16]([NH:31][C:13](=[O:19])[CH:14]=2)=[O:18])[CH:25]=[CH:26][CH:27]=1

참가 물질

6

반응물 5

HCID 1140TolueneHCID 6395Methanesulfonic AcidHCID 7923Maleic AnhydrideHCID 8471TriethylamineHCID 108243-Methoxyaniline

생성물 1

HCID 212246183-(3-Methoxyphenyl)-1H-pyrrole-2,5-dione

실험 절차

Toluene (100 mL), triethylamine (10 g), methanesulfonic acid (15 g) were placed into a 500 ml, single-neck flask. Maleic anhydride (21.0 g, 214 millimoles) was dissolved into this mixture. This mixture was stirred magnetically at room temperature and m-anisidine (24.67 g, 200 millimoles) was then added drop-wise over a twenty minute period. A Dean-Stark trap and condenser were attached and the mixture was refluxed for three hours. A total of 3.7 ml of water was collected in the trap. The mixture was cooled to room temperature and the upper (toluene) phase was decanted off. The lower phase was extracted with 6×70 ml portions of fresh toluene. The collected toluene phase was passed over 27 grams of silica gel. The toluene was removed on a rotary evaporator to yield 27.3 g (67% of theory) of a clear yellow liquid. The product crystallized to a solid upon standing at room temperature. The solid melted at 75-76.5° C.

후처리

  1. temperaturethe mixture was refluxed for three hours
  2. customA total of 3.7 ml of water was collected in the trap
  3. temperatureThe mixture was cooled to room temperature
  4. customthe upper (toluene) phase was decanted off
  5. extractionThe lower phase was extracted with 6×70 ml portions of fresh toluene
  6. customThe toluene was removed on a rotary evaporator
  7. customto yield 27.3 g (67% of theory) of a clear yellow liquid
  8. customThe product crystallized to a solid
  9. customupon standing at room temperature

출처 및 근거

ORD 기록
ord-ec7bbaddd49f44bd916aa50a947d9ab9
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08378017B2

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