Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoyl isothiocyanate → 1-Benzoyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]thiourea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoyl isothiocyanate | HCID 68284 | — |
| 반응물 | 4-Amino-1-(2-naphthyl)methylpiperidine | HCID 11195823 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 1-Benzoyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]thiourea | HCID 12942346 | — |
반응 단계
4-Amino-1-(naphth-2-ylmethyl)piperidine (1.0 g, 0.0042 m) and benzoylisothiocyanate (0.69 g, 0.0042 m) in toluene (120 cm3) was stirred at room temperature for 6 hours. The solvent was evaporated and the gum dissolved in isopropyl alcohol and acidified with ethanolic HCl. The solvent was evaporated and the residue dissolved in ethyl acetate. The title compound crystallised and was filtered and dried as the monohydrochloride quarterhydrate salt, m.p. 212°-214° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04722930 |
| 출처 데이터셋 | uspto-grants-1988_02 |
| ORD ID | ord-abd517df60204610939cf68a6c24b096 |
| 출처 메모 | uspto-grants-1988_02 |