Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(1-Methylpyrrolidin-2-yl)pyridine → (R)-Nicotine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(1-Methylpyrrolidin-2-yl)pyridine | HCID 942 | — |
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | dibenzoyl-L(+)tartaric acid | HCID 12362976 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (R)-Nicotine | HCID 157672 | 57.6% |
반응 단계
A mixture of dibenzoyl-l-tartaric acid (58 g, 0.154 mol), 100 ml isopropanol and (R,S)-nicotine (25 g, 0.154 mol) was stirred for 1 hr and heated to reflux. While refluxing, 50 ml methanol was added and continued as in Example 1 to get (R)-nicotine (7.2 g, 57.6% yield) 99.85% GC, optical rotation: +141°, 99.9% chiral purity by HPLC.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08378111B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-39b0e72307044c84870e7de79c6b53c9 |
| 출처 메모 | uspto-grants-2013_02 |