Phosphorus oxychloride → 7-Bromo-1-chloro-6-methoxyisoquinoline

참여 물질

반응 단계

A mixture of the product from Step 2 (4.7 g, 18.5 mmol) in phosphorus oxychloride (30 mL) was heated to reflux for 2 hours and cooled to RT; the volatiles were evaporated; and the residue was partitioned between 3 M NaOH and DCM. The organic phase was dried over Na2SO4; the solvent was evaporated; and the solid was triturated with Et2O (20 mL) and filtered to give the title compound (3.75 g). LRMS ESI+ (M+H)+ 274.0.

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