4-Toluenesulfonyl chloride → HCID 59287022, 화합물

HRID 389210노트

반응식

HRID 389210 반응식
[Br:1][C:2]1[CH:3]=[N+:4]([O-])[C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([O:12][CH3:13])[CH:6]=2.S(Cl)(C1C=CC(C)=CC=1)(=O)=[O:16]>CCOC(C)=O.C([O-])([O-])=O.[K+].[K+]>[Br:1][C:2]1[C:3](=[O:16])[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([O:12][CH3:13])[CH:6]=2

참가 물질

5

반응물 2

HCID 73974-Toluenesulfonyl chlorideHCID 592871093-Bromo-7-methoxyquinoline 1-oxide

생성물 1

HCID 59287022HCID 59287022, 화합물

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 11430Potassium Carbonate용매

실험 절차

To a solution of 3-bromo-7-methoxyquinoline 1-oxide (2.04 g, 8.03 mmol) in EtOAc (50 mL) and 15% aqueous K2CO3 (15 mL) at RT, TsCl (1.68 g, 8.83 mmol) was added. The reaction mixture was stirred vigorously at RT for 18 hours, at which time the product was collected by filtration and washed with EtOAc. The solid was dried under vacuum and used with no further purification. LRMS (M+H)+=254.1.

후처리

  1. filtrationwas collected by filtration
  2. washwashed with EtOAc
  3. customThe solid was dried under vacuum
  4. customused with no further purification

출처 및 근거

ORD 기록
ord-02a1070da8bb4b269567a34eb3011c5a
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08377874B2

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