1,2-Dichlorobenzene → 1-(5-carboxypentyl)-5-methoxy-2,3,3-trimethyl-3H-indolium bromide

HRID 389242노트

반응식

HRID 389242 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[C:6]2([CH3:14])[CH3:13].[Br:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22].ClC1C=CC=CC=1Cl>C(OCC)C>[Br-:15].[C:21]([CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][N+:8]1[C:9]2[C:5](=[CH:4][C:3]([O:2][CH3:1])=[CH:11][CH:10]=2)[C:6]([CH3:14])([CH3:13])[C:7]=1[CH3:12])([OH:23])=[O:22]

참가 물질

5

반응물 3

HCID 72391,2-DichlorobenzeneHCID 202106-Bromohexanoic acidHCID 110953925-Methoxy-2,3,3-trimethyl-3H-indole

생성물 1

HCID 688166851-(5-carboxypentyl)-5-methoxy-2,3,3-trimethyl-3H-indolium bromide수율 80.9%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
10 °C

실험 절차

To 5-methoxy-2,3,3-trimethyl-3H-indole (1.9 g) was added 6-bromohexanoic acid (3 g) and 1,2-dichlorobenzene (10 ml). The mixture was heated to 10° C. for 3 hours and then allowed to cool to room temperature. Diethyl ether was added and the precipitated material removed by filtration. Drying in a vacuum oven gave the product (3.12 g).

후처리

  1. temperatureto cool to room temperature
  2. customthe precipitated material removed by filtration
  3. customDrying in a vacuum oven

출처 및 근거

ORD 기록
ord-08752a76977a4ffdb8415baf6b48d1da
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08378120B2

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