Water → 7-methoxy-2,3-dihydro-1H-inden-4-ol
반응식
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([O:12]C)=[C:8]2[C:4]=1[CH2:5][CH2:6][CH2:7]2.B(Br)(Br)Br.O>C(Cl)Cl>[CH3:1][O:2][C:3]1[C:4]2[CH2:5][CH2:6][CH2:7][C:8]=2[C:9]([OH:12])=[CH:10][CH:11]=1참가 물질
5
반응 조건
- 온도
- 5 °C
실험 절차
To the clear solution of 4,7-Dimethoxyindane (22.5 gm, 0.126 mole) in Methylene chloride (400 ml), added Boron tribromide (12.27 ml, 0.13 mole) at 0° C. After 2 hours stirring at 0-10° C., water (100 ml) was added and then the reaction mixture was extracted with Methylene chloride. The Methylene chloride layer was dried over Sodium sulphate and distilled off to give a crude mass which was purified by column chromatography using 7% Ethyl acetate in Hexane (9.0 gm).
후처리
- extractionthe reaction mixture was extracted with Methylene chloride
- dry with materialThe Methylene chloride layer was dried over Sodium sulphate
- distillationdistilled off
- customto give a crude mass which
- customwas purified by column chromatography
출처 및 근거
- ORD 기록
- ord-6dc2ab116f0b42ac90f202ae09650e77
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08378118B2
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