Calcium Carbonate → strontium bis((2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate)

HRID 389328

반응식

HRID 389328 반응식
[O:1]=[C:2]1[O:8][C@H:7]([C@H:9]([CH2:11][OH:12])[OH:10])[C:5]([O-:6])=[C:3]1[OH:4].[Sr:13].[Ca].[O:15]=[C:16]1[O:22][C@H:21]([C@H:23]([CH2:25][OH:26])[OH:24])[C:19]([OH:20])=[C:17]1[OH:18].C(=O)([O-])[O-].[Sr+2].C(=O)([O-])[O-].[Ca+2]>O>[O:1]=[C:2]1[O:8][C@H:7]([C@H:9]([CH2:11][OH:12])[OH:10])[C:5]([O-:6])=[C:3]1[OH:4].[Sr+2:13].[O:15]=[C:16]1[O:22][C@H:21]([C@H:23]([CH2:25][OH:26])[OH:24])[C:19]([O-:20])=[C:17]1[OH:18]

참가 물질

8

반응물 6

HCID 10112Calcium CarbonateHCID 15407Strontium carbonateHCID 5359327StrontiumHCID 5460341CalciumHCID 54670067L-Ascorbic Acid3회HCID 178519208HCID 178519208, 화합물

생성물 1

HCID 140483007strontium bis((2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate)

시약·촉매·용매 1

HCID 962Water용매3회

실험 절차

The following reaction is carried out to form a strontium (M) ascorbate salt using ascorbate, strontium and calcium where the Sr:Ca mole ratio is 0.6 moles Sr:0.4 moles Ca. Ascorbic acid is dissolved in distilled H2O at 90° C. in an appropriate reaction vessel (Meuller). The water mass is 10-25% of the mass of ascorbic acid. As soon as the ascorbic acid is dissolved, slowly add strontium carbonate followed by calcium carbonate. Keep temperature constant. As the reaction proceeds, add 0.5-5% water by mass. Reduce temperature to 60° C. 10 minutes after the last of the mineral salt is added. The resulting slurry is transferred to trays and placed in the oven at 60° C. until dry. Optionally, the strontium ascorbate (M) salt may need to be turned over once as part of the drying process. The dry strontium ascorbate (M) salt mass can be milled to varying particle sizes including a fine powder or a granular powder for use in various oral dosage forms.

후처리

  1. customto 60° C
  2. addition10 minutes after the last of the mineral salt is added
  3. customplaced in the oven at 60° C.
  4. customuntil dry
  5. customThe dry strontium ascorbate (M) salt mass can be milled

출처 및 근거

ORD 기록
ord-d45a331ab5d94e4c81dbefa4d3f74c73
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08378126B2

연결된 노트

불러오는 중…