(2S,3R,4S,5R)-2,3,4,5-Tetrahydroxycyclohexanone → HCID 44511908, 화합물

HRID 389373노트

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HRID 389373 반응식
[CH2:1]1[C:6](=[O:7])[C@@H:5]([OH:8])[C@H:4]([OH:9])[C@@H:3]([OH:10])[C@@H:2]1O>O>[OH:10][C@@H:3]1[C@@H:4]([OH:9])[C@H:5]([OH:8])[C:6](=[O:7])[CH:1]=[CH:2]1

참가 물질

3

반응물 1

HCID 10583108(2S,3R,4S,5R)-2,3,4,5-Tetrahydroxycyclohexanone

생성물 1

HCID 44511908HCID 44511908, 화합물수율 41.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1.64 g of 2-deoxy-scyllo-inosose synthesized according to the method described in WO 2006/112000 and 5 mL of an ion exchange resin IR120B were added to 13.6 mL of water, and the resulting mixture was heated at reflux for 20 hours. After the completion of the reaction, the ion exchange resin was filtered and the filtrate was concentrated under a reduced pressure. The condensation residue was purified with silica gel column (ethyl acetate), whereby 604 mg (yield: 41%) of (4S,5R,6S)-4,5,6-trihydroxy-2-cyclohexene-1-one was obtained.

후처리

  1. temperaturethe resulting mixture was heated
  2. temperatureat reflux for 20 hours
  3. customAfter the completion of the reaction
  4. filtrationthe ion exchange resin was filtered
  5. concentrationthe filtrate was concentrated under a reduced pressure
  6. customThe condensation residue was purified with silica gel column (ethyl acetate)

출처 및 근거

ORD 기록
ord-0b6e73355eb044b994887eabe1c841a7
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08378146B2

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