Water → (2S,3R,4S)-2,3,4-Trihydroxycyclohexanone

HRID 389374노트

반응식

HRID 389374 반응식
[OH:1][C@@H:2]1[C@@H:7]([OH:8])[C@H:6]([OH:9])[C:5](=[O:10])[CH:4]=[CH:3]1.O>CO.[Pd]>[OH:8][C@H:7]1[C@H:6]([OH:9])[C@@H:5]([OH:10])[CH2:4][CH2:3][C:2]1=[O:1]

참가 물질

5

반응물 2

HCID 962WaterHCID 44511908HCID 44511908, 화합물

생성물 1

HCID 45082801(2S,3R,4S)-2,3,4-Trihydroxycyclohexanone수율 96%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

205 mg of (4S,5R,6S)-4,5,6-trihydroxy-2-cyclohexene-1-one obtained in Example 3 was dissolved in 3.5 mL of methanol. 20 mg (50 weight % of water contained) of 5 weight % Pd/C was added thereto and hydrogenated at room temperature (25 degrees centigrade) under ordinary pressure (1 atm). After the completion of the reaction, the catalyst was removed by filtration, and the filtrate was concentrated to obtain 198 mg (yield: 96%) of (2S,3R,4S)-2,3,4-trihydroxycyclohexane-1-one.

후처리

  1. customhydrogenated at room temperature
  2. custom(25 degrees centigrade)
  3. customAfter the completion of the reaction
  4. customthe catalyst was removed by filtration
  5. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-c25bac5a1b794539b0ff197a9ac631f9
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08378146B2

반응 노트

불러오는 중…