Toluene → 1-(2-Amino-5-chlorophenyl)-2,2,2-trifluoroethanone

HRID 389400노트

반응식

HRID 389400 반응식
O.Cl.[NH2:3][C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[C:11](=[O:16])[C:12]([F:15])([F:14])[F:13].C1(C)C=CC=CC=1.C([O-])(O)=O.[Na+]>O>[NH2:3][C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[C:11](=[O:16])[C:12]([F:15])([F:13])[F:14]

참가 물질

5

반응물 3

HCID 1140TolueneHCID 516892Sodium BicarbonateHCID 441819891-(2-Amino-5-chlorophenyl)-2,2,2-trifluoroethan-1-one--hydrogen chloride--water (1/1/1)

생성물 1

HCID 109878821-(2-Amino-5-chlorophenyl)-2,2,2-trifluoroethanone수율 98%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone hydrochloride hydrate (48.5 g, 174.4 mmol), 300 mL toluene, and 150 mL water was stirred at room temperature for 30 minutes. The pH of the solution was adjusted to 7-8 via the addition of saturated aqueous NaHCO3 solution. The resulting mixture was then separated, and the toluene layer was collected and evaporated to dryness to give 38.2 g 1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone (2) as a yellow solid.

후처리

  1. customThe resulting mixture was then separated
  2. customthe toluene layer was collected
  3. customevaporated to dryness

출처 및 근거

ORD 기록
ord-fada4446c00c49f2901602a3feaaa21c
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08378143B2

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