1,3-Cyclohexanediol → 3-(Tert-butyldimethylsilanyloxy)cyclohexanol

반응식

[CH:1]1([OH:8])[CH2:6][CH2:5][CH2:4][CH:3]([OH:7])[CH2:2]1.[Si:9](OC1CCC(N2CC(B3OC(C)(C)C(C)(C)O3)=CN2)C1)([C:12]([CH3:15])([CH3:14])[CH3:13])([CH3:11])[CH3:10]>>[C:12]([Si:9]([CH3:11])([CH3:10])[O:7][CH:3]1[CH2:4][CH2:5][CH2:6][CH:1]([OH:8])[CH2:2]1)([CH3:15])([CH3:14])[CH3:13]

참가 물질

반응물 2

HCID 104331,3-Cyclohexanediol

HCID 667595192-[3-(tert-butyldimethylsilanyloxy)-cyclopentyl]-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

생성물 1

HCID 5570773-(Tert-butyldimethylsilanyloxy)cyclohexanol수율 35%

실험 절차

The title compound was prepared in 35% yield from 1,3-cyclohexanediol by a procedure analogous to Intermediate 28, Step A. 1H NMR (300 MHz, CDCl3): δ 4.0-4.2 (m, 1H), 3.8-3.95 (m, 1H), 1.3-2.4 (m, 9H), 0.86 (s, 9H), 0.05 (s, 6H).

출처 및 근거

ORD 기록: ord-952be78ea2404a4b9f2eea420bff95c3
출처 데이터셋: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08378104B2

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