Methylamine → HCID 85873295, 화합물

HRID 389576노트

반응식

[Br:1][C:2]1[C:10]2[S:9][C:8](Cl)=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH3:12][NH2:13]>>[Br:1][C:2]1[C:10]2[S:9][C:8]([NH:13][CH3:12])=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 6329Methylamine

HCID 667605757-BroMo-2-chlorobenzothiazole

생성물 1

HCID 85873295HCID 85873295, 화합물수율 67.7%

반응 조건

온도: 60 °C

실험 절차

7-Bromo-2-chlorobenzothiazole (85 mg, 0.34 mmol) and methylamine (2 M in THF, 3 mL, 6 mmol) were mixed and heated to 60° C. overnight. The solvent was evaporated. The residue was purified by ISCO chromatography (0 to 30% EtOAc:heptane) to afford 56 mg (67%) of the title compound. MS (ESI): 243.30, 245.26 [M+H]+; HPLC tR=1.09 min (HPLC: Anayltical—2 min).

후처리

customThe solvent was evaporated
customThe residue was purified by ISCO chromatography (0 to 30% EtOAc:heptane)

출처 및 근거

ORD 기록: ord-f1b015357b124e8792248a6824282a77
출처 데이터셋: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08378104B2

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