Ethylamine → HCID 86662423, 화합물

HRID 389578노트

반응식

[Br:1][C:2]1[C:10]2[S:9][C:8](Cl)=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH2:12]([NH2:14])[CH3:13]>>[Br:1][C:2]1[C:10]2[S:9][C:8]([NH:14][CH2:12][CH3:13])=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 6341Ethylamine

HCID 667605757-BroMo-2-chlorobenzothiazole

생성물 1

HCID 86662423HCID 86662423, 화합물수율 92.4%

반응 조건

온도: 70 °C

실험 절차

7-Bromo-2-chlorobenzothiazole (100 mg, 0.40 mmol) was added to ethylamine (2.0 M in THF, 1 mL, 2 mmol) and the solution was heated at 70° C. for 1 h. The crude mixture was purified by ISCO chromatography (100% DCM) to afford 95 mg (92%) of the title compound as white solid. MS (ESI): 257.33, 259.31 [M+H]+; HPLC tR=1.27 min (HPLC: Anayltical—2 min).

후처리

customThe crude mixture was purified by ISCO chromatography (100% DCM)

출처 및 근거

ORD 기록: ord-a04e12605a564cd59f26245caa8b4306
출처 데이터셋: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08378104B2

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