Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
m-Chloroperbenzoic acid → 5-Bromo-2-(oxiran-2-ylmethoxy)phenyl formate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 5-Bromo-2-(oxiran-2-ylmethoxy)benzaldehyde | HCID 21220982 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 5-Bromo-2-(oxiran-2-ylmethoxy)phenyl formate | HCID 21221027 | — |
반응 단계
To a solution of 5-bromo-2-(oxiran-2-ylmethoxy)benzaldehyde (12.3 g, 47.7 mmol) in DCM (50 ml) was added m-CPBA (12.8 g, 57.2 mmol). The solution was heated at reflux for 3 h and 30 min and then brought to ambient temperature. Aqueous sodium bicarbonate (saturated) and DCM was added and the phases were separated. The organic phase was washed with brine, dried (Na2SO4), filtered and evaporated to dryness to give the crude title compound. Crude yield: 12.3 g. MS m/z (rel. intensity, 70 eV) 272 (M+, 7), 244 (50), 189 (95), 188 (bp), 57 (93).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524766B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-767b3078aa2d471d93d3027cc3832986 |
| 출처 메모 | uspto-grants-2013_09 |