Water → 4-(2-Hydroxyacetyl)benzonitrile

HRID 389880노트

반응식

HRID 389880 반응식
Br[CH2:2][C:3]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1)=[O:4].[OH2:13]>C(#N)C>[OH:13][CH2:2][C:3]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1)=[O:4]

참가 물질

4

반응물 2

HCID 962WaterHCID 986544-(Bromoacetyl)benzonitrile

생성물 1

HCID 179928864-(2-Hydroxyacetyl)benzonitrile

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 1 g of 4-(2-bromoacetyl)benzonitrile in acetonitrile (5 mL) and water (10 mL) is treated under microwave irradiation (125° C., 50 min). The same experiment is conducted five times. All the vials are collected, extracted with ethyl ether, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.

후처리

  1. customAll the vials are collected
  2. extractionextracted with ethyl ether
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-103dc8cfdc194c609774dca0383cc9eb
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383608B2

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