Ethanol → 3-[2,5-Dioxo-4-[(2-propenyloxy)methyl]imidazolidin-4-yl]benzonitrile

HRID 389886노트

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HRID 389886 반응식
[CH2:1]([O:4][CH2:5][C:6]([C:8]1[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=1C#N)=O)[CH:2]=[CH2:3].O.[C-:17]#[N:18].[K+].[C:20](=[O:23])([O-])[O-].[NH4+:24].[NH4+:25].C[CH2:27][OH:28]>>[O:28]=[C:27]1[NH:25][C:6]([C:8]2[CH:9]=[C:12]([CH:13]=[CH:14][CH:15]=2)[C:17]#[N:18])([CH2:5][O:4][CH2:1][CH:2]=[CH2:3])[C:20](=[O:23])[NH:24]1

참가 물질

6

반응물 5

HCID 702EthanolHCID 962WaterHCID 9032Potassium CyanideHCID 517111Ammonium CarbonateHCID 86641460(2-(2-Propenyloxy)acetyl]benzonitrile

생성물 1

HCID 671310093-[2,5-Dioxo-4-[(2-propenyloxy)methyl]imidazolidin-4-yl]benzonitrile

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온도
55 °C

실험 절차

To a solution of 450 mg of 3-[(2-(2-propenyloxy)acetyl]benzonitrile (in EtOH (5 mL) and water (5 mL) 291 mg of potassium cyanide and ammonium carbonate are added. The mixture is refluxed one night at 55° C. The mixture is extracted with ethyl acetate, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.

후처리

  1. extractionThe mixture is extracted with ethyl acetate
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-39ff7f05feeb4343b34cfb265185d649
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383608B2

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