Water → 2-Hydroxy-3'-(trifluoromethyl)acetophenone

HRID 389890노트

반응식

HRID 389890 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[CH:6]=1)=[O:4].[OH2:15]>C(#N)C>[F:12][C:11]([F:14])([F:13])[C:7]1[CH:6]=[C:5]([C:3](=[O:4])[CH2:2][OH:15])[CH:10]=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 962WaterHCID 27783862-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one

생성물 1

HCID 167269582-Hydroxy-3'-(trifluoromethyl)acetophenone

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone (1 g) in acetonitrile (2.5 mL) and water (10 mL) is treated under microwave irradiation (125° C., 50 min). The same experiment is repeated five times. All the vials are collected, extracted with DCM, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.

후처리

  1. customAll the vials are collected
  2. extractionextracted with DCM
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-ba55c46c5d4f44f2a5e9f3d295235304
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383608B2

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