1-Methyl-3-pyrrolidinol, (-)- → (R)-3-Hydroxy-1-methyl-1-(pyridazin-3-ylcarbamoylmethyl)-pyrrolidinium bromide
반응식
[Br:1][CH2:2][C:3]([NH:5][C:6]1[N:7]=[N:8][CH:9]=[CH:10][CH:11]=1)=[O:4].[OH:12][C@@H:13]1[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14]1>C(#N)C>[Br-:1].[OH:12][CH:13]1[CH2:17][CH2:16][N@@+:15]([CH3:18])([CH2:2][C:3](=[O:4])[NH:5][C:6]2[N:7]=[N:8][CH:9]=[CH:10][CH:11]=2)[CH2:14]1참가 물질
4
실험 절차
A stirred suspension of 2-bromo-N-pyridazin-3-yl-acetamide (0.5 g, 2.31 mmol) in acetonitrile (10 ml) is treated with (R)-3-hydroxy-1-methyl pyrrolidine (0.234 g, 2.31 mmol). The suspension is stirred at room temperature for 2 hours and then filtered and washed with acetonitrile to yield the titled compound.
후처리
- filtrationfiltered
- washwashed with acetonitrile
출처 및 근거
- ORD 기록
- ord-76142c7e79534258ad41ca5c98de419c
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08383625B2
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