Benzilic acid → (1r/s,3r)-3-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-methyl-1-(pyrazin-2-yl-carbamoyl-methyl)-pyrrolidinium bromide
반응식
[Br-:1].C1(C(O)(C2C=CC=CC=2)C(O[CH:12]2[CH2:16][CH2:15][CH2:14][N+:13]2([CH3:27])[CH:17]([C:21]2[CH:26]=[N:25][CH:24]=[CH:23][N:22]=2)[C:18](=[O:20])[NH2:19])=O)CCCCC1.[C:35]([OH:51])(=[O:50])[C:36]([C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)[OH:37]>>[Br-:1].[OH:37][C:36]([C:44]1[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=1)([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)[C:35]([O:51][C@@H:16]1[CH2:15][CH2:14][N+:13]([CH3:27])([CH:17]([C:21]2[CH:26]=[N:25][CH:24]=[CH:23][N:22]=2)[C:18](=[O:20])[NH2:19])[CH2:12]1)=[O:50]참가 물질
3
실험 절차
This compound is prepared by an analogous method to (1R/S,3R)-3-((R/S)-(2-cyclohexyl-2-hydroxy-2-phenyl-acetoxy)-1-methyl-1-(pyrazin-2-ylcarbamoylmethyl)-pyrrolidinium bromide (Example 1) by replacing cyclohexyl-hydroxy-phenyl-acetic acid with benzilic acid.
출처 및 근거
- ORD 기록
- ord-8332f730aa044703b7b98fdd89ac44b8