Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 389974생성일: 2026년 10월 25일
Tetrahydrofuran → [4-(6-Aminopyridin-3-YL)piperazin-1-YL]-(2-trifluoromethylphenyl)methanone
https://huagongshe.com/reaction/389974
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | [4-(6-Nitropyridin-3-yl)piperazin-1-yl]-(2-trifluoromethylphenyl)-methanone | HCID 39235237 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | [4-(6-Aminopyridin-3-YL)piperazin-1-YL]-(2-trifluoromethylphenyl)methanone | HCID 67419145 | 49% |
반응 단계
To a solution of [4-(6-nitropyridin-3-yl)piperazin-1-yl]-(2-trifluoromethylphenyl)-methanone (0.089 g, 0.23 mmol) in 1:1 THF:MeOH (5 mL) was added 10% Pd/C (0.051 g). The resulting mixture was stirred under hydrogen atmosphere at 25° C. for 4 h. After filtering through a celite cake, the solution was concentrated in vacuo and yielded the title compound as a light yellow solid (0.039 g, 49% yield). MS (ES+) m/z 351.3.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08383628B2 |
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| 출처 데이터셋 | uspto-grants-2013_02 |
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| ORD ID | ord-0486ccf4f3a8436299ae344700d3b835 |
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| 출처 메모 | uspto-grants-2013_02 |
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