Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperazine → 1-(4-Cyclohexylphenyl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | 1-Bromo-4-cyclohexylbenzene | HCID 90718 | — |
| 반응물 | Sodium t-butoxide | HCID 23676156 | — |
| 촉매 | HCID 178424406 | HCID 178424406 | — |
| 생성물 | 1-(4-Cyclohexylphenyl)piperazine | HCID 2757996 | — |
반응 단계
A target compound (2.01 g, 8.224 mmol, 45.7%) was yielded in the same manner as Reference Example 10 by reacting 1-bromo-4-cyclohexylbenzene (3.34 mL, 18 mmol) with piperazine (2.01 g, 23.4 mmol), sodium t-butoxide (2.51 g, 26.1 mmol) and dichlorobis(tri-o-tolylphosphine)palladium(II) (424.4 mg, 0.54 mmol) and purifying by separation through column chromatography (CH2Cl2/MeOH, 1:1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383631B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-a6956ce0a8d04c79bd00f551e8a34bc6 |
| 출처 메모 | uspto-grants-2013_02 |