Water → (7-Bromo-5-fluoro-2,3-dihydro-1,4-benzodioxin-2-yl)methanol

HRID 39001노트

반응식

HRID 39001 반응식
C([O:4][C:5]1[CH:10]=[C:9]([Br:11])[CH:8]=[C:7]([F:12])[C:6]=1[O:13][CH2:14][CH:15]1[CH2:17][O:16]1)(=O)C.[OH-].[K+].O.[OH-].[K+].O>O1CCOCC1>[Br:11][C:9]1[CH:8]=[C:7]([F:12])[C:6]2[O:13][CH2:14][CH:15]([CH2:17][OH:16])[O:4][C:5]=2[CH:10]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 23719240Potassium hydroxide monohydrateHCID 866529445-Bromo-3-fluoro-2-(oxiran-2-ylmethoxy)phenyl acetate

생성물 1

HCID 66878254(7-Bromo-5-fluoro-2,3-dihydro-1,4-benzodioxin-2-yl)methanol수율 35%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

5-bromo-3-fluoro-2-(oxiran-2-ylmethoxy)phenyl acetate (2.6 g, 8.7 mmol) was stirred in dioxane at RT. Aqueous KOH (10%) was added until basic pH was reached (1:1 water/KOH (10%)). Water was added and the solution was extracted with EtOAc: The combined organic phases were washed with brine, dried and evaporated to dryness to give the title compound (0.8 g). MS m/z (rel. intensity, 70 eV) 263 (M+, 97), 262 (M+, bp), 218 (39), 207 (50), 206 (51).

후처리

  1. extractionthe solution was extracted with EtOAc
  2. washThe combined organic phases were washed with brine
  3. customdried
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-debd2a7d3a8e4bb0a2c4384046cb343e
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524766B2

반응 노트

불러오는 중…