Potassium Carbonate → 1-{2-[(2R)-Oxiran-2-ylmethoxy]-5-[(trifluoromethyl)sulfonyl]phenyl}ethanone

HRID 39011

반응식

HRID 39011 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]([F:14])([F:13])[F:12])(=[O:10])=[O:9])=[CH:4][C:3]=1[C:15](=[O:17])[CH3:16].[CH2:18](OS(C1C=CC(C)=CC=1)(=O)=O)[C@@H:19]1[O:21][CH2:20]1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[O:21]1[CH2:20][C@@H:19]1[CH2:18][O:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]([F:14])([F:12])[F:13])(=[O:10])=[O:9])=[CH:4][C:3]=1[C:15](=[O:17])[CH3:16]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 154187Glycidyl tosylate, (R)-HCID 668781541-{2-Hydroxy-5-[(trifluoromethyl)sulfonyl]phenyl}ethanone

생성물 1

HCID 866529481-{2-[(2R)-Oxiran-2-ylmethoxy]-5-[(trifluoromethyl)sulfonyl]phenyl}ethanone

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Preparation according to Preparation 23 using 1-{2-hydroxy-5-[(trifluoromethyl)sulfonyl]phenyl}ethanone (3.2 g, 11.9 mmol), (R)-glycidyltosylate (3.2 g, 14 mmol), K2CO3 (2.0 g, 14.3 mmol) and DMF (30 ml). Yield 2.2 g. MS m/z (rel. intensity, 70 eV) 324 (M+, 4), 277 (83), 255 (69), 253(67), 199 (bp).

후처리

  1. customPreparation

출처 및 근거

ORD 기록
ord-57961e4a3bc24e0cafecf9a851d6072b
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524766B2

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