Acetone → 2-(Benzyloxy)-1-chloro-3-fluorobenzene

HRID 39015노트

반응식

HRID 39015 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[OH:9].C([O-])([O-])=O.[K+].[K+].[CH3:16][C:17]([CH3:19])=O>>[CH2:16]([O:9][C:3]1[C:4]([F:8])=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1])[C:17]1[CH:19]=[CH:4][CH:3]=[CH:2][CH:7]=1

참가 물질

4

반응물 3

HCID 180AcetoneHCID 11430Potassium CarbonateHCID 27737102-Chloro-6-fluorophenol

생성물 1

HCID 532169822-(Benzyloxy)-1-chloro-3-fluorobenzene

반응 조건

온도
65 °C

실험 절차

A mixture of 2-chloro-6-fluorophenol (25 g, 170 mmol), acetone (200 ml), K2CO3 (47.08 g, 340 mmol) and bensylbromide (22.31 ml, 187 mmol) was heated at 65° C. for 16 h. The solution was filtered and evaporated. Water (100 ml) was added, and the solution was extracted with EtOAc. The combined organic phases were dried (Na2SO4) and evaporated to dryness to give the title compound (32.3 g). MS m/z (rel. intensity, 70 eV) 236 (M+, 2), 117 (4), 92 (8), 91 (bp), 65 (13).

후처리

  1. filtrationThe solution was filtered
  2. customevaporated
  3. additionWater (100 ml) was added
  4. extractionthe solution was extracted with EtOAc
  5. dry with materialThe combined organic phases were dried (Na2SO4)
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-38288b2fe72543d2874ba82dd88f7891
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524766B2

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