Potassium Hydroxide → [(2S)-8-Fluoro-2,3-dihydro-1,4-benzodioxin-2-YL]methanol

HRID 39018노트

반응식

HRID 39018 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH2:9][CH:10]2[CH2:12][O:11]2)[C:3]=1[OH:13].[OH-].[K+]>O1CCOCC1>[F:1][C:2]1[C:3]2[O:13][C@@H:10]([CH2:12][OH:11])[CH2:9][O:8][C:4]=2[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 866529502-Fluoro-6-(oxiran-2-ylmethoxy)phenol

생성물 1

HCID 54461939[(2S)-8-Fluoro-2,3-dihydro-1,4-benzodioxin-2-YL]methanol

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Preparation according to Preparation 20 using 2-fluoro-6-(oxiran-2-ylmethoxy)phenol (3.9 g, 21.2 mmol), dioxane (20 ml) and KOH (10%, 10 ml). The mixture stirred at RT for 1.5 h. Yield 3.8 g. MS m/z (rel. intensity, 70 eV) 338 (50), 166 (bp), 165 (42), 139 (24), 91 (51).

후처리

  1. customPreparation

출처 및 근거

ORD 기록
ord-6c5afa6cfb53451ba6c1042974bb7319
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524766B2

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