3-(2-Chlorophenyl)propanoic acid → 2-(7-Chloro-1'-(3-(2-chlorophenyl)propanoyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid

HRID 390190

반응식

HRID 390190 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][C:10](O)=[O:11].[Cl:13][C:14]1[CH:15]=[CH:16][CH:17]=[C:18]2[C:27]=1[C:21]1([CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)[CH2:20][CH:19]2[CH2:28][C:29]([O:31]CC)=[O:30]>>[Cl:13][C:14]1[CH:15]=[CH:16][CH:17]=[C:18]2[C:27]=1[C:21]1([CH2:22][CH2:23][N:24]([C:10](=[O:11])[CH2:9][CH2:8][C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])[CH2:25][CH2:26]1)[CH2:20][CH:19]2[CH2:28][C:29]([OH:31])=[O:30]

참가 물질

3

실험 절차

The title compound was prepared following a procedure analogous to that described in Example 1 using 3-(2-chlorophenyl)propanoic acid and ethyl 2-(7-chloro-2,3-dihydrospiro[indene-1,4′-piperidine]-3-yl)acetate followed by a procedure analogous to that in Example 2. LC-MS Method 1 tR=1.87, min, m/z=446

출처 및 근거

ORD 기록
ord-303b22150aca4edc9c24f486f8152fec
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383629B2

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