Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonic acid → 4-Chloro-2-(dimethoxymethyl)-1-nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | Trimethyl orthoformate | HCID 9005 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 5-Chloro-2-nitrobenzaldehyde | HCID 81123 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-Chloro-2-(dimethoxymethyl)-1-nitrobenzene | HCID 3570093 | — |
반응 단계
A mixture of 5-chloro-2-nitro-benzaldehyde (0.0792 mol), trimethoxy-methane (0.126 mol) and PTSA (0.00079 mol) in methanol (80 mL) was refluxed until the 5-chloro-2-nitro-benzaldehyde had completely reacted. The mixture was cooled, Na2CO3 was added, and the reaction mixture was stirred for 5 min. The mixture was filtered and the filtrate was evaporated under reduced pressure to yield the title compound as a residue.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383637B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-c09d9ce853a64bd1aeca3b6ad66cd3c9 |
| 출처 메모 | uspto-grants-2013_02 |