Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3-(4-Hydroxyphenyl)hex-4-ynoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 5-(1-(4-Hydroxyphenyl)but-2-yn-1-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione | HCID 59855133 | — |
| 용매 | Pyridine water | HCID 66926435 | — |
| 생성물 | 3-(4-Hydroxyphenyl)hex-4-ynoic acid | HCID 59855136 | 96% |
반응 단계
A solution of 5-[1-(4-hydroxyphenyl)but-2-ynyl]-2,2-dimethyl-1,3-dioxane-4,6-dione (20 g, 69.44 mmol) in pyridine-water (5:1, 390 mL) is heated at reflux for 16 hours and after cooling is acidified to pH ˜2 with 5 N HCl and extracted with EtOAc (2×300 mL). The combined extracts are washed with saturated brine, dried over MgSO4, filtered, and concentrated to give an off-white solid (13.5 g, 96%). ESI/MS m/z 203 (M−H)−.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383642B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-45f98b47da3b415db8f3f616c25e4520 |
| 출처 메모 | uspto-grants-2013_02 |