Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 5-(3,4-Dichlorophenyl)-3-(pyridin-3-yl)isoxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 3,4-Dichlorophenylacetylene | HCID 44119622 | — |
| 반응물 | N-Hydroxy-3-pyridinecarboximidoyl chloride | HCID 53404818 | — |
| 생성물 | 5-(3,4-Dichlorophenyl)-3-(pyridin-3-yl)isoxazole | HCID 44546158 | — |
반응 단계
The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 1,2-dichloro-4-ethynylbenzene (Aldrich, 86 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.69 (dd, J=8.1, 5.0 Hz, 1H), 7.82-8.00 (m, 3H), 8.21 (d, J=2.0 Hz, 1H), 8.38 (dt, J=7.9, 1.8 Hz, 1H), 8.78 (dd, J=4.8, 1.6 Hz, 1H), 9.14 (d, J=1.2 Hz, 1H) ppm; MS (DCI/NH3) m/z 293 (M+H)+, 291 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383658B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-c72680dddf0c469598b3edf1cb8f618f |
| 출처 메모 | uspto-grants-2013_02 |