Ammonia → 5-(3,4-Dichlorophenyl)-3-(pyridin-3-yl)isoxazole

HRID 390434

반응식

HRID 390434 반응식
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]#[CH:19])=[CH:14][C:13]=1[Cl:20].N>>[Cl:20][C:13]1[CH:14]=[C:15]([C:18]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=3)[CH:19]=2)[CH:16]=[CH:17][C:12]=1[Cl:11]

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 441196223,4-DichlorophenylacetyleneHCID 53404818N-Hydroxy-3-pyridinecarboximidoyl chloride

생성물 1

HCID 445461585-(3,4-Dichlorophenyl)-3-(pyridin-3-yl)isoxazole

실험 절차

The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 1,2-dichloro-4-ethynylbenzene (Aldrich, 86 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.69 (dd, J=8.1, 5.0 Hz, 1H), 7.82-8.00 (m, 3H), 8.21 (d, J=2.0 Hz, 1H), 8.38 (dt, J=7.9, 1.8 Hz, 1H), 8.78 (dd, J=4.8, 1.6 Hz, 1H), 9.14 (d, J=1.2 Hz, 1H) ppm; MS (DCI/NH3) m/z 293 (M+H)+, 291 (M+H)+.

출처 및 근거

ORD 기록
ord-c72680dddf0c469598b3edf1cb8f618f
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383658B2

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