Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 5-(3-Fluoro-4-(trifluoromethoxy)phenyl)-3-(pyridin-3-yl)isoxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 4-Ethynyl-2-fluoro-1-(trifluoromethoxy)benzene | HCID 16218253 | — |
| 반응물 | N-Hydroxy-3-pyridinecarboximidoyl chloride | HCID 53404818 | — |
| 생성물 | 5-(3-Fluoro-4-(trifluoromethoxy)phenyl)-3-(pyridin-3-yl)isoxazole | HCID 44546160 | — |
반응 단계
The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 4-ethynyl-2-fluoro-1-(trifluoromethoxy)benzene (Apollo, 102 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.69 (dd, J=8.0, 4.9 Hz, 1H), 7.78-7.96 (m, 3H), 8.11 (dd, J=11.0, 1.9 Hz, 1H), 8.38 (dt, J=8.1, 1.9 Hz, 1H), 8.79 (dd, J=4.9, 1.2 Hz, 1H), 9.15 (d, J=1.0 Hz, 1H) ppm; MS (DCI/NH3) m/z 325 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383658B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-c6813cda6da64487a8c38c2dbfb012a5 |
| 출처 메모 | uspto-grants-2013_02 |