Ammonia → 5-(4-Fluorophenyl)-3-(pyridin-3-yl)isoxazole

HRID 390438

반응식

HRID 390438 반응식
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[C:11]([C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)#[CH:12].N>>[F:19][C:16]1[CH:17]=[CH:18][C:13]([C:11]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=3)[CH:12]=2)=[CH:14][CH:15]=1

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 5226271-Ethynyl-4-fluorobenzeneHCID 53404818N-Hydroxy-3-pyridinecarboximidoyl chloride

생성물 1

HCID 445461625-(4-Fluorophenyl)-3-(pyridin-3-yl)isoxazole

실험 절차

The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 1-ethynyl-4-fluorobenzene (Aldrich, 60 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.40-7.52 (m, 2H), 7.70-7.81 (m, 2H), 7.92-8.08 (m, 2H), 8.44 (dt, J=8.0, 1.9 Hz, 1H), 8.80 (d, J=4.4 Hz, 1H), 9.18 (s, 1H) ppm; MS (DCI/NH3) m/z 241 (M+H)+.

출처 및 근거

ORD 기록
ord-94d051ac40e74450995f8cc53bfa44d0
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383658B2

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