Ammonia → 5-(3,5-Difluorophenyl)-3-(pyridin-3-yl)isoxazole

HRID 390439

반응식

HRID 390439 반응식
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[C:11]([C:13]1[CH:18]=[C:17]([F:19])[CH:16]=[C:15]([F:20])[CH:14]=1)#[CH:12].N>>[F:19][C:17]1[CH:18]=[C:13]([C:11]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=3)[CH:12]=2)[CH:14]=[C:15]([F:20])[CH:16]=1

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 42068061-Ethynyl-3,5-difluorobenzeneHCID 53404818N-Hydroxy-3-pyridinecarboximidoyl chloride

생성물 1

HCID 445461635-(3,5-Difluorophenyl)-3-(pyridin-3-yl)isoxazole

실험 절차

The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 1-ethynyl-3,5-difluorobenzene (Apollo, 69 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.50 (tt, J=9.3, 2.4 Hz, 1H), 7.60-7.78 (m, 3H), 7.89 (s, 1H), 8.32 (dt, J=7.8, 2.2 Hz, 1H), 8.76 (d, J=3.4 Hz, 1H), 9.11 (d, J=1.7 Hz, 1H) ppm; MS (DCI/NH3) m/z 259 (M+H)+.

출처 및 근거

ORD 기록
ord-a1baba11210640dd87eab376a3de60f1
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383658B2

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