Ammonia → 5-(3-Fluorophenyl)-3-(pyridin-3-yl)isoxazole

참여 물질

역할	이름	HCID	투입량
반응물	Ammonia	HCID 222	—
반응물	1-Ethynyl-3-fluorobenzene	HCID 520218	—
반응물	N-Hydroxy-3-pyridinecarboximidoyl chloride	HCID 53404818	—
생성물	5-(3-Fluorophenyl)-3-(pyridin-3-yl)isoxazole	HCID 44546223	—

반응 단계

The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 1-ethynyl-3-fluorobenzene (Aldrich, 60 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.35-7.51 (m, 1H), 7.60-7.82 (m, 4H), 7.84 (s, 1H), 8.42 (dt, J=8.1, 1.7 Hz, 1H), 8.80 (dd, J=5.0, 1.4 Hz, 1H), 9.17 (d, J=1.6 Hz, 1H) ppm; MS (DCI/NH3) m/z 241 (M+H)+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08383658B2
출처 데이터셋	uspto-grants-2013_02
ORD ID	ord-c9dd3195296b4b4a85420eb9e3c68bec
출처 메모	uspto-grants-2013_02