Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 3-(3-(5-Fluoropyridin-3-yl)isoxazol-5-yl)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 3-Ethynylbenzonitrile | HCID 12088964 | — |
| 반응물 | 5-Fluoro-N-hydroxynicotinimidoyl chloride | HCID 86636846 | — |
| 생성물 | 3-(3-(5-Fluoropyridin-3-yl)isoxazol-5-yl)benzonitrile | HCID 44546287 | — |
반응 단계
The titled compound was prepared according to Method CB using the product of Example 28B (88 mg, 0.5 mmol) and the product of Example 19A (64 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.55 (s, 1H), 7.75 (t, J=7.9 Hz, 1H), 7.88 (dt, J=7.9, 1.4 Hz, 1H), 8.18 (ddd, J=9.3, 2.8, 1.8 Hz, 1H), 8.23 (ddd, J=7.9, 2.0, 1.2 Hz, 1H), 8.31 (t, J=1.6 Hz, 1H), 8.62 (d, J=2.8 Hz, 1H), 8.98 (t, J=1.6 Hz, 1 H) ppm; MS (DCI/NH3) m/z 266 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383658B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-44d5ca19e8cc4beea375f60dd735de39 |
| 출처 메모 | uspto-grants-2013_02 |